On Monday Night Football, Manning completed 24 of 30 passes (80 percent) for 309 yards with three touchdowns versus one interception and a 129 passer rating in the Broncos' 35-24 win at San Diego.
Helped the Broncos overcome a 24-0 deficit and become the first team in NFL history to win by double digits after trailing by at least 24.
Registered his 47th career game-winning drive in the fourth quarter or overtime to tie Pro Football Hall of Famer Dan Marino for the most by a player since 1970. Led all AFC quarterbacks with 129 passer rating and had an NFL-best 80 percent completion percentage in Week 6.
Posted his 67th career 300-yard passing game, the most in NFL history. Through Week 6, Manning leads the AFC with 14 touchdown passes.
In his 15th season from Tennessee, Manning has 22 career Player of the Week Awards, the most since the award originated in 1984. He most recently won the award in 2010 (Week 14) with the Indianapolis Colts.
Most Conference Player Of Week Awards
1. Peyton Manning* - 22
2. Tom Brady* - 21
3. Dan Marino - 18
4. Drew Brees* - 16
4. Brett Favre - 16
6. John Elway - 15